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SLB, A NEW ALLOANTIGENIC SYSTEM OF THE PIG
Author(s) -
Hruban V.,
Hradecký J.,
Pazdera J.,
Simon M.,
Veselský L.
Publication year - 1978
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1978.tb00643.x
Subject(s) - locus (genetics) , biology , allele , abo blood group system , histocompatibility , antigen , genetics , lod score , human leukocyte antigen , genetic linkage , major histocompatibility complex , gene , gene mapping , chromosome
SUMMARY An alloantigen segregating in the double back‐cross families, distinct from serologically determinable transplantation antigens controlled by the major histocompatibility complex (SLA), was detected in pigs by the complementdependent lymphocytotoxic technique. The system was designated SLB and its product (antigen SLB‐Al) was demonstrated in all lymphocytes from the lymph nodes, thymus and peripheral blood, but not in the erythrocytes. Back‐cross matings supplied evidence of the dominant heredity of SLB‐Al. Detection of further SLB antigens was unsuccessful, so that only two alleles (SLB‐Al and SLB‐A‐) could be determined in families. Double back‐cross families revealed a close linkage between the SLB locus and the L blood group locus. Maximum lod score values were calculated in recombination fraction θ= 0.10.