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HISTOCOMPATIBILITY ANTIGENS AND GENETIC CONTROL OF THE IMMUNE RESPONSE IN GUINEA‐PIGS
Author(s) -
Geczy A. F.,
Weck A. L. de
Publication year - 1977
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1977.tb00920.x
Subject(s) - immune system , antigen , biology , haplotype , major histocompatibility complex , histocompatibility , guinea pig , gene , antibody , strain (injury) , immunology , genetics , human leukocyte antigen , allele , anatomy
SUMMARY Further breeding studies were carried out to investigate the polygenic control of the cellular immune response in the guinea‐pig to low doses of aspirin anhydride (ASAN), penicilloylated bovine immunoglobulin (BPO‐BGG) and to the multi‐chain copolymer (T, G)‐A–L. Although responsiveness to these three antigens is controlled by three independently segregating loci, at least one gene required for these responses is linked to the strain 13 haplotype.