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SEGREGATION OF HLA HAPLOTYPES IN 100 FAMILIES WITH A MYASTHENIA GRAVIS PATIENT
Author(s) -
BergLoonen Ella M. vanden,
Nijenhuis L. E.,
Engelfriet C. P.,
Feltkamp T. E. W.,
Rossum A. L. van,
Oosterhuis H. J. G. H.
Publication year - 1977
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1977.tb00916.x
Subject(s) - myasthenia gravis , haplotype , human leukocyte antigen , immunology , medicine , biology , genetics , allele , antigen , gene
SUMMARY An analysis of the HLA data of 100 myasthenia gravis (MG) patients and their first degree relatives and spouses is presented. The family studies confirmed the excess of B8 in the myasthenia gravis patients and showed that the excess was not limited to the A1, B8 haplotype. An excess of B8 homozygous patients was found from the matings of two B8 heterozygous parents, suggesting the existence of a dominant B8 linked MG susceptibility. B8 homozygous individuals run a 4.7 times higher risk of acquiring myasthenia gravis than B8 heterozygous individuals.