Premium
DOUBLE LINE PHENOTYPES IN RABBIT IgG ALLOTYPES AND THEIR RELATION TO THE CIS/TRANS CONFIGURATION OF THE IgG MARKERS
Author(s) -
HamersCasterman C.,
Wittouck E.,
Florent G.,
Loo W. van der,
Baetselier P. De,
Hamers R.
Publication year - 1977
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1977.tb00913.x
Subject(s) - allotype , locus (genetics) , phenotype , biology , allele , genetics , precipitin , gene , microbiology and biotechnology , antigen
SUMMARY Rabbit antiallotype sera raised against heavy chain markers sometimes show double precipitin lines with all or some of the corresponding antigens (double and single line phenotypes). In a number of cases the double line phenotypes behave as alleles of the single line phenotypes and this feature allows a genetic and immunochemical analysis of these systems. In three cases that have been analysed, the double line phenotype arises when a precipitating a locus allotype and a non‐precipitating d or e locus allotype are present on the same molecule (a1 and d14), (a1 and d11), (a3 and d11). This only happens when the corresponding genes are present on the same chromosome ( cis configuration) of the diploid pair. These sera are therefore useful for determining directly the genotype of the animals.