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A STUDY OF THE INCREASED SERUM LEVEL OF IgG 1 IN ‘LETHARGIC’ MICE COMBINED WITH A DEPRESSED THYMUS‐DEPENDENT LYMPHOID SYSTEM
Author(s) -
Dung H. C.,
Lawson R. L.,
Stevens M.,
Walker Gail A.
Publication year - 1977
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1977.tb00911.x
Subject(s) - spleen , radial immunodiffusion , lymphatic system , mutant , lymph , biology , mutation , medicine , immunology , endocrinology , antibody , pathology , genetics , gene
SUMMARY In a series of recent studies on ‘lethargic’ mice, a neurological mutation of the mouse, significant abnormalities were discovered in the thymus and its dependent regions in the lymph nodes and spleen. The present study was made as an approach toward finding the possible causes for these abnormalities. Serum IgG 1 levels were studied in ‘lethargic’ mutants at the age when severe deficiency of the thymus‐dependent lymphoid system is known to occur in the animal. Using the radial immunodiffusion method, it was found that serum IgG 1 levels are always significantly higher in ‘lethargic’ mice than in their normal littermates. Possible causes of the higher IgG 1 in the serum of ‘lethargic’ mice are discussed. The authors note the similarities of other mouse mutations to that of the ‘lethargic’ mouse and propose the possibility that a common mechanism may account for immunologic deficiencies in several types of mutant mice.