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STUDIES ON NON‐H‐2 LINKED LYMPHOCYTE ACTIVATING DETERMINANTS I. DESCRIPTION OF THE CELL TYPE BEARING THE MLS PRODUCT
Author(s) -
Ahmed A.,
Scher I.,
Smith A. H.,
Sell K. W.
Publication year - 1977
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1977.tb00902.x
Subject(s) - immunoglobulin d , biology , lymphocyte , immunology , complement receptor , surface immunoglobulin , receptor , population , antibody , complement (music) , locus (genetics) , major histocompatibility complex , complement system , microbiology and biotechnology , genetics , b cell , antigen , medicine , gene , phenotype , complementation , environmental health
SUMMARY The non‐H‐2 linked, lymphocyte activating determinants (LADs), which are coded by the minor (histocompatibility) lymphocyte stimulating locus (Mls), were detected on B lymphocytes, but not on immunoglobulin (Ig) negative or on theta positive T lymphocytes. These determinants, like the complement receptor and surface IgD, develop late in neonatal life. Thus, the Mls coded LADs mark a population of B lymphocytes which are not present in the spleens of newborn to 2‐week‐old mice. Studies of B lymphocytes derived from the spleens of adult mice indicated that the cells that bear the Mls coded LADs have a high density of surface Ig and possess the complement receptor.