Premium
COINCIDENT EFFECT IN THE GRAFT‐VERSUS‐HOST REACTION OF BALB/c LYMPHOID CELLS DERIVED FROM MICE IMMUNE EITHER TO ALLOGENEIC NORMAL TISSUE OR TO SYNGENEIC CHEMICALLYINDUCED FIBROSARCOMATA
Author(s) -
Parmiani G.,
Invernizzi G.
Publication year - 1977
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1977.tb00900.x
Subject(s) - balb/c , immune system , fibrosarcoma , spleen , antigen , transplantation , immunology , biology , graft vs host reaction , serology , microbiology and biotechnology , histocompatibility , lymphatic system , antibody , bone marrow , medicine , bone marrow transplantation , human leukocyte antigen , genetics , surgery
SUMMARY By using the graft‐versus‐host reaction (GVHR) based on the spleen enlargement test of Simonsen (1962), lymphocytes from BALB/c mice immune to syngeneic ST2 or ST5 sarcomata were shown to behave like BALB/c anti‐DBA/2 lymphocytes in specifically increasing the GVHR in (BALB/c × DBA/2)F 1 newborns as compared with non‐immune BALB/c cells. No such effect was evident when BALB/c anti‐ST2 or anti‐ST5 lymphoid cells were given to (BALB/c × C3Hf)F 1 and to (BALB/c × AKR)F 1 mice; anti‐ST5 lymphocytes were also ineffective into (BALB/c × C57BL/6)F 1 newborns in which anti‐ST2 lymphocytes were able to increase the GVHR over the background induced by non‐immune BALB/c cells. A third immunogenic BALB/c fibrosarcoma C‐1 was able to activate syngeneic lymphocytes which gave an augmented GVHR in (BALB/c × C3Hf)F 1 and (BALB/c × AKR)F 1 but not in the other hybrids. The efficacy of BALB/c anti‐ST2 or ‐ST5 lymphocytes in reproducing a BALB/c anti‐DBA/2 like anamnestic response in (BALB/c × DBA/2)F 1 mice support previous findings indicating that non‐H‐2 alien histocompatibility antigens of the DBA/2 strain, are expressed on these tumour cells. The GVHR induced by lymphoid cells immune to C‐1 tumour are also in keeping with serological and transplantation studies (reported elsewhere) indicating the expression of foreign H‐2 k antigens on this sarcoma.