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THE USE OF EARLY EMBRYO AGGREGATION DERIVED MOUSE CHIMAERAS. III. A TOOL OF IMMUNOGENETICS *
Author(s) -
Barnes R. D.
Publication year - 1976
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1976.tb00604.x
Subject(s) - immunogenetics , allotype , biology , antibody response , embryo , immune system , computational biology , antibody , immunology , genetics
SUMMARY Early embryo aggregation derived chimaeras have proven a valuable tool to biologists concerned with various aspects of mammalian development. The use of this model is discussed here in respect of its application to the field of immunogenetics and also to possible future exploitation. Chimaeras have already provided information concerning various areas of immunogenetics ranging from tolerance, control of antibody response, allotype expression, gene transfer and its possible influence upon the immune response. These are reviewed here.