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THE USE OF EARLY EMBRYO AGGREGATION DERIVED MOUSE CHIMAERAS. II. THE STUDY OF DISEASE PROCESSES *
Author(s) -
Barnes R. D.
Publication year - 1976
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1976.tb00603.x
Subject(s) - biology , disease , embryo , population , immune system , immunology , genetics , pathology , medicine , environmental health
SUMMARY Early embryo aggregation derived mouse chimaeras have proven an extremely valuable tool to study development of disease processes. In this respect chimaeras prove a unique opportunity to study the interaction between cells genetically predestined to become diseased and a normal cell population within the same animal. In this situation chimaeras can be studied in view of possible ‘correction’ of the disease by the provision of a population of normal host cells and/or their products. Various host deficiency states including classic immune deficiency, potentially ‘deficient’ anaemias and tumours have been studied–the subject of the review here.