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CHARACTERISTICS OF NATURAL ANTI‐NP ANTI‐BODIES IN DIFFERENT STRAINS OF MICE
Author(s) -
Julin Marja
Publication year - 1976
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1976.tb00590.x
Subject(s) - allotype , antibody , biology , titer , gene , genetics
SUMMARY Characteristics (titre and fine‐specificity) of natural anti‐NP* antibodies were determined in eighteen inbred strains of mice. We found systematic titre and fine‐specificity differences between different strains. At least five types of strains could be easily detected but the data indicate that the actual number is greater. Strains sharing an Ig allotype tended to have less different anti‐NP antibodies than those not sharing the allotype. Fine‐specificity of natural anti‐NP antibodies resembled fine‐specificity characteristics in immune anti‐NP antibodies of the same strains. Both are probably controlled by V genes. The data indicate that fine‐specificity of antibodies has a great resolving power in the study of Mendelian V genes.