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FAILURE TO SUPPRESS THETA ANTIGENIC EXPRESSION IN PROGENY DERIVED FROM PRE‐IMMUNIZED MATERNAL RECIPIENTS
Author(s) -
Braun Colette,
Mahouy G.,
Bona C.,
GoujetZalc Cécile,
Tuffrey Maureen,
Crewe Pamela,
Barnes R.
Publication year - 1976
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1976.tb00589.x
Subject(s) - antigen , biology , expression (computer science) , immunology , virology , computer science , programming language
SUMMARY One possible theory concerning the success of the fetus as an allograft has been attributed to maternal modification of foreign fetal antigenic expression. In this respect progeny derived from pre‐immunized maternal mouse recipients, have been examined for any modification (reduction) of corresponding θ antigen determinants. Two major groups of mice were examined. The first group of embryo transplantation derived AKR homozygotes born from pre‐immunized CBA recipients whilst producing the corresponding anti‐θ AKR antibody activity. The second group of naturally derived reciprocal (CBA × AKR)FI heterozygotes were also born from pre‐immunized maternal recipients. In neither group was θ expression found to be modified and the significance of this finding is discussed in respect of other situations where fetal antigenic expression is known to be altered by maternal influence.