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GENETIC CONTROL OF THE IMMUNE RESPONSE TO FERRITIN IN MICE
Author(s) -
Young C. R.,
Deacon N. J.,
Ebringer A.,
Davies D. A. L.
Publication year - 1976
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1976.tb00573.x
Subject(s) - ferritin , immune system , biology , antigen , antibody , spleen , gene , immunology , immunization , horse , immunity , genetics , biochemistry , paleontology
SUMMARY The immune response to the antigen horse spleen ferritin was tested in sixteen inbred strains of mice. Using a fixed antigen percentage bound isotope technique, it was found that the quantity of antibody produced was related to the genetic status of the responding animal. A continuous distribution of responses was obtained, which were found to be linked to H‐2 loci and the 2 non‐H‐2 loci ‘Tla’ and ‘Theta’ and these responses are detectable following primary immunization. It is suggested that the continuous distribution of quantitative antibody responses to ferritin, is compatible either with a large number of IR‐genes or with a cross tolerance hypothesis requiring no IR‐genes at all.