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THE MAJOR HISTOCOMPATIBILITY COMPLEX OF THE GUINEA‐PIG
Author(s) -
Geczy A. F.,
Weck A. L. de
Publication year - 1976
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1976.tb00572.x
Subject(s) - biology , guinea pig , locus (genetics) , major histocompatibility complex , antigen , allele , histocompatibility , genetics , inbred strain , gene , immunology , human leukocyte antigen
SUMMARY The relationship between the mixed leucocyte reaction (MLR) and the serologically‐defined antigens controlled by genes in the guinea‐pig B locus (equivalent to the murine D or K region) and I region was investigated in various inbred and partially inbred strains and in guinea‐pig families homozygous for their GPLA alleles. No MLR reactions could be detected among guinea‐pig families of a closed colony which had been bred to homozygosity for their GPLA antigens. By contrast, animals which differed in their I region showed strong MLR reactivity. Animals with identical I regions as judged by four serologically‐defined specificities only, but differ with respect to B locus determinants, yield appreciably lower MLR responses. It appears that in the guinea‐pig, as in other mammalian species, the antigenic systems responsible for MLR reactivity are controlled primarily by genes identical with or closely linked to the I region of the major histocompatibility complex.