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DETECTION OF A 1 A 2 AND A 2 A A m 1 HETEROZYGOTES AMONG HUMAN A BLOOD GROUP PHENOTYPES
Author(s) -
Cartron J. P.,
Ropars C.,
ČAlkovská Zdenka,
Salmon Ch.
Publication year - 1976
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1976.tb00568.x
Subject(s) - heterozygote advantage , biology , phenotype , genotype , genetics , microbiology and biotechnology , gene
SUMMARY From the variations of α‐N‐acetylgalactosaminyltransferases activities with the pH, evidence was obtained for the recognition of A 1 A 2 heterozygotes in normal A blood group sera. Besides, unusual transferase properties associated with two A 2 sera from individuals out of A A m 1 siblings, lead to the identification of the very infrequent A 2 A A m 1 genotypes. These results strongly support the simultaneous coexistence of both A 1 and A 2 transferases in heterozygotes' sera, and bring some new information on the genetical background of the A m phenotype. The meaning of transferase properties directly determined on whole sera is briefly discussed.