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JUVENILE DIABETES MELLITUS: HLA‐ANTIGEN FREQUENCIES DEPENDENT ON THE AGE OF ONSET OF THE DISEASE
Author(s) -
Schernthaner G.,
Ludwig H.,
Mayr W. R.
Publication year - 1976
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1976.tb00562.x
Subject(s) - diabetes mellitus , human leukocyte antigen , medicine , age of onset , juvenile , disease , incidence (geometry) , type 1 diabetes , immunology , antigen , endocrinology , biology , genetics , physics , optics
SUMMARY A close correlation between juvenile diabetes mellitus and HLA‐B8, HLA‐BW15 and HLA‐CW3 was found. Association of these antigens with juvenile diabetes mellitus was closely dependent on the ages of onset of the disease. Frequencies of BW15 and CW3 showed a remarkably low incidence in the childhood diabetics (0–15 years old) and were found increased in the patients with later (16 years or older) onset diabetes. HLA‐B8 frequencies were found increased in all the groups of diabetics with different ages of onset. These findings point to the importance of HLA‐B8 in childhood and HLA‐B8, BW15 and CW3 in the later onset juvenile onset diabetes mellitus (JOD).