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GENETIC STUDIES IN INBRED RATS. VI. LINKAGE RELATIONSHIPS OF MIXED LYMPHOCYTE REACTIVITY, SEROLOGICALLY DEFINED ANTIGENS (Ag‐B, Ag‐C) AND THE IMMUNE RESPONSE TO POLY(Glu 52 Lys 33 Tyr 15 )
Author(s) -
Shonnard J. W.,
Cramer D. V.,
Poloskey P. E.,
Davis Bridgett K.,
Gill T. J.
Publication year - 1976
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1976.tb00556.x
Subject(s) - immune system , mixed lymphocyte reaction , allotype , biology , antigen , lymphocyte , immunogenetics , backcrossing , genetics , antibody , genetic linkage , histocompatibility , immunology , locus (genetics) , microbiology and biotechnology , gene , human leukocyte antigen , t cell
SUMMARY The Ag‐B allotype, mixed lymphocyte reactivity (MLR) and the immune response to poly(Glu 52 Lys 33 Tyr 15 ) were assayed in male rats from the F2 hybrid and two back‐cross generations of the F344 and DA strains in order to investigate the structure of the rat major histocompatibility complex. No disparity between Ag‐B type and mixed lymphocyte reactivity was found in 263 animals. The immune response to poly(Glu 52 Lys 33 Tyr 15 ) was closely linked to the Ag‐B locus, and both antibody production and the delayed hypersensitivity response were under polygenic control. These results suggest that the genetic loci which determine these responses in the rat are closely linked and that recombinational events between the Ag‐B and MLR loci are infrequent.