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COMPARATIVE IMMUNOGENICITY OF THY‐1.1 AND THY‐1.2 ANTIGENS
Author(s) -
Staines N. A.,
O'Neill G. J.
Publication year - 1975
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1975.tb00526.x
Subject(s) - congenic , immunogenicity , antigen , strain (injury) , biology , antibody , gene , microbiology and biotechnology , haplotype , immunology , allele , genetics , anatomy
SUMMARY The immunogenicity of Thy‐1 antigens was examined using the Thy‐1 congenic mouse strains A and A/Thy‐1.1. A disequilibrium of response was found between these strains. A strain mice rejected skin grafts and produced high titres of antibody to lymphoid cells from A/Thy‐1.1 strain mice. However, in the reverse combination grafts were not rejected nor was there any significant antibody response. A/Thy‐1.1 mice did not respond to Thy‐1.2 antigen when it was presented on an H‐2 allogeneic background (A·SW strain) but did respond to it when non‐H‐2 incompatibilities were involved (B10·A strain donor). We postulate the existence of Ir gene(s) for the response to Thy‐1.2 antigens which are linked to H‐2. The failure of A/Thy‐1.1 strain mice to respond to Thy‐1.2 antigens in the absence of carrier determinants is the result of a deletion (in the germ line) of the appropriate Ir gene itself resulting from the long association of the H‐2 a haplotype of the A mouse (donor of the genetic background of A/Thy‐1.1 strain) with the Thy ‐1.2 gene.