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A POSSIBLE GENETIC SOLUTION OF THE AUSTRALIA HEPATITIS (B) ANTIGEN
Author(s) -
Tovell T. R.
Publication year - 1975
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1975.tb00513.x
Subject(s) - trimer , antigen , gene , dimer , antibody , hepatitis b , hepatitis , virology , genetics , biology , chemistry , organic chemistry
SUMMARY By applying the gene template structure (Tovell & Vos, 1973) to a series of observations made by Soulier & Couroucé‐Pauty (1973) a probable solution to the genetics of the Australia Hepatitis (B) antigen is presented. Since the gene template structure proposed for antigens is of monomer, dimer and trimer structure–similar to antibody structure–this appears to mean that the Hepatitis antigen complex is similar. It is also likely that the determinants used to identify the Hepatitis antigens cut through the genetic systems and that most of them repeat in two or more ‘genetic antigens’. A total of seventy‐three coincidences in nineteen groups of observation is reported, and there were no observations reported that did not coincide.