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THE IMMUNE RESPONSE OF CHACMA BABOONS TO INTRAVENOUS AND INTRAMUSCULAR INJECTIONS OF HUMAN RED CELLS AND THE DEMONSTRATION OF POSSIBLE SIMILARITIES TO RH ISOIMMUNIZATION
Author(s) -
Vos G. H.,
Downing H. J.
Publication year - 1975
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1975.tb00503.x
Subject(s) - antibody , fetus , immunology , immune system , biology , intramuscular injection , antigen , red cell , immunization , pregnancy , physiology , endocrinology , medicine , andrology , genetics
SUMMARY The present study has shown that the intramuscular injection of human red cells into baboons can often produce long lasting antibodies of the IgG variety. The intravenous administration of human red cells into baboons sometimes fails to stimulate the production of antibodies to the first injection but after a second injection short duration IgG and IgM antibodies are generally observed. A similar pattern of antibody behaviour was also seen in a postnatal follow‐up study of Rh immunized women. Of significance was the finding that some women were able to make long lasting high titred Rh antibodies whilst others frequently produced antibodies which decreased in intensity shortly after pregnancy. It is postulated that the formation of long lasting high titred Rh antibodies may be due to the intrauterine trapping of fetal Rh incompatible cells during parturition, while the formation of antibodies which show a marked decrease in intensity may result from the passage of fetal cells into the maternal blood circulation. Different in vivo pathways of antibody formation are indicated for the two modes of red cell antigen presentation.