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A SKIN‐GRAFT ENHANCING ANTISERUM WHICH RECOGNIZES TWO NEW B‐CELL ALLOANTIGENS DETERMINED BY THE MAJOR HISTO‐COMPATIBILITY LOCUS OF THE MOUSE
Author(s) -
Archer J. R.,
Smith Daphne A.,
Davies D. A. L.,
Staines N. A.
Publication year - 1974
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1974.tb00321.x
Subject(s) - antiserum , spleen , biology , lymph node , cytotoxic t cell , antibody , lymph , microbiology and biotechnology , immunology , absorption capacity , pathology , genetics , medicine , in vitro , chemical engineering , engineering
SUMMARY A mouse alloantiserum, raised by immunizing B10.D2/n mice with B10.M spleen, has been found to retain cytotoxic activity against a proportion of lymph node cells even after exhaustive absorption with B10.M red blood cells. Titration and absorption with a number of strains showed that the absorbed serum retained antibodies against two new specificities. The absorbed serum gave significant enhancement of B10.M skin grafts on B10.D2 and reacted mainly with B cells.