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FOUR NEW HL‐A ALLELIC FACTORS SUBTYPIC TO HL‐A12 AND W15. THEIR CORRELATION WITH W4 AND W6
Author(s) -
Richiardi P.,
Castagneto M.,
D'Amaro J.,
Schreuder I.,
Vassalli P.,
Curtoni E. S.
Publication year - 1974
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1974.tb00320.x
Subject(s) - biology , allele , locus (genetics) , population , genetics , immunology , gene , medicine , environmental health
SUMMARY Several anti‐HL‐A antisera, correlated with either HL‐A12 or W15, were studied. Immunogenetic analysis was carried out by population and family studies, adsorptions, elutions and resistance to lysis induction capacity. Antibodies present in the sera allow the distinction to be made between two alternative factors subtypic to HL‐A12,‘TO 50’and‘TO 51′, and two alternative factors subtypic to W15,‘TO 52’and‘TO 53′. These subdivisions are genetically determined. Lysostrip experiments demonstrated them to be on the same molecule carrying either HL‐A 12 or W15. Thus, they enable the identification of new locus FOUR allelic products. These new HL‐A factors are strictly correlated with W4 and W6: haplotypic association has regularly been found between TO 50 and W4, TO 51 and W6, TO 52 and W4, TO 53 and W6. This subdivision of HL‐A allelic products into specificities subtypic either to W4 or to W6 is a characteristic common to most, if not all, FOUR factors. Finally, the commonly observed cross‐reaction between W15 and W17 preferably takes place with TO 52. It should be noted that both TO 52 and W17 are subtypic to W4.