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THE GENETIC LINKAGE OF THE IMMUNE RESPONSE TO POLY(Glu 52 Lys 33 Tyr 15 ) TO THE MAJOR HISTOCOMPATIBILITY LOCUS IN INBRED RATS *
Author(s) -
Kunz Heinz W.,
Gill, III Thomas J.,
Borland Barbara
Publication year - 1974
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1974.tb00315.x
Subject(s) - allele , histocompatibility , locus (genetics) , antibody , major histocompatibility complex , genetics , biology , genotype , inbred strain , genetic linkage , immune system , antibody response , antigen , microbiology and biotechnology , gene , human leukocyte antigen
SUMMARY The genetic control of the antibody response to poly(Glu 52 Lys 33 Tyr 15 ) was studied in twenty‐five strains of inbred rats representing a wide variety of major histocompatibility groups. Direct linkage studies, and three subsidiary lines of evidence, demonstrated that the control was linked to the major histocompatibility locus. All of the low responders (Ag‐B1, 3 and 6) made less than 65 μg of antibody/ml. In contrast, there were quantitatively significant differences among responders: the Ag‐B2 group was a moderate responder (200–500 μg antibody/ml) and the Ag‐B4 and Ag‐B5 groups were high responders (700–1400 μg/ml). The ability to form antibody segregated with the major histocompatibility allele in the F2 and back‐cross generations. Genetic factors other than those controlling the ability to respond influence the quantity of antibody formed: animals of the same genotype can make significantly different amounts of antibody, depending upon the crosses by which they acquire the major histocompatibility alleles.