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IMMUNOGLOBULIN LEVELS IN SUBJECTS WITH SEX CHROMOSOME ABNORMALITIES
Author(s) -
Price William H.,
Newlands Irene M.,
Ferguson Thomas
Publication year - 1974
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1974.tb00309.x
Subject(s) - karyotype , biology , antibody , endocrine system , chromosome , medicine , endocrinology , physiology , immunology , genetics , hormone , gene
SUMMARY Immunoglobulins A, G and M have been measured in three groups of patients with sex chromosome abnormalities, 47,XXY, 47,XYY and 47,XXX. The most significant finding is a greatly elevated IgG level in 47,XXY males and 47.XYY males. In the case of 47,XXY males it was possible to show that the increase in level was almost confined to those who were patients in mental subnormality and maximum security hospitals. Only a few abnormally high IgG values were found in patients referred to endocrine clinics. Low IgA levels were found in institutionalized patients whether or not chromosome abnormalities were present. In 47,XXY males IgM levels were significantly higher than in 46,XY males and the same as those in 46.XX females. Although serious illnesses were recorded in a high proportion of males with a 47,XXY karyotype, the level of IgG was not closely related to a history of disease. Possible reasons for the findings are discussed.