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OBTENTION OF HISTOCOMPATIBLE STRAINS IN THE URODELE AMPHIBIAN PLEURODELES WALTLII MICHAH. ( SALAMANDRIDAE )
Author(s) -
Charlemagne J.,
Tournefier Annick
Publication year - 1974
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1974.tb00299.x
Subject(s) - biology , heterozygote advantage , mendelian inheritance , locus (genetics) , genetics , histocompatibility , allele , antigen , gene , human leukocyte antigen
SUMMARY Histocompatibility antigens have been studied by skin grafting in three successive generations of the Urodele Pleurodeles waltlii Michah. Starting from a brother‐sister pair of animals (F 1 ) mutually tolerant, the descendence obtained in F 2 is composed of three types of animals called A/A, A/B, B/B according to their mutual capacity for tolerance or rejection. The three types are numerically divided according to the mendelian proportions of monohybridism, that is 25 % of A/A, 50% of A/B and 25% of B/B. All the descendants (F 3 ) born of homozygote parents A/A or B/B are homozygote. The descendants (F 3 ) born of heterozygote parents A/B are composed of type A/A, A/B and B/B animals in mendelian proportions of mono‐hybridism. The presence of histocompatibility antigens A and B would be determined by a pair of dominant alleles which are on a locus carried by the same pair of chromosomes.