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PRECIPITATING ANTIBODIES IN THE SERA OF TRANSFUSED PATIENTS: POSSIBLE CONFUSION WITH ANTI‐AU
Author(s) -
Blumberg Baruch S.,
Hann HieWon L.,
Thomas London W.,
Yin LokKee
Publication year - 1974
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1974.tb00295.x
Subject(s) - precipitin , confusion , antigen , antibody , immunology , immunodiffusion , medicine , hepatitis , virology , biology , psychology , psychoanalysis
SUMMARY The Ag system, inherited antigenic determinants on serum low density lipoprotein and Australia antigen (Au), an antigen associated with an infectious agent which can cause hepatitis in man were discovered by reacting in immunodiffusion tests sera from multiply transfused patients and sera from geographically human populations. The approach has been pursued in the experiments described herein and has resulted in the identification of seventeen precipitating systems. They are different from the previously described anti‐Au and anti‐Ag precipitins. In some cases they may be confused with Australia antigen precipitins, and care should be taken in the evaluation of Au test systems where comparisons with antigen controls are not routinely performed.