Premium
AN AMINO ACID DELETION ASSOCIATED WITH THE IgG4b ALLOTYPE OF HUMAN IgG4 MYELOMA PROTEINS
Author(s) -
Abel C. A.,
Despont J. P.
Publication year - 1974
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1974.tb00294.x
Subject(s) - allotype , myeloma protein , antibody , peptide sequence , amino acid , biochemistry , leucine , peptide , chemistry , microbiology and biotechnology , biology , immunology , gene
SUMMARY Comparative aminoacid sequence studies were done on chymotryptic peptides from the Fc fragments of IgG1, IgG2, IgG4a and IgG4b human myeloma proteins. Eleven peptides were positioned within the Fc fragments of IgG4 proteins. While leucine was present at position 309 of the Fc fragment of the IgG4a protein, it was absent from the Fc fragment of the IgG4b protein.