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IgG1 SUBCLASS PROTEIN WITH THE GENETIC Gm MARKERS Gm(z + non‐a +): ANOTHER EXAMPLE OF INTRAGENIC HYBRIDIZATION AMONG IgG SUBCLASS GENES
Author(s) -
Natvig J. B.,
Michaelsen T. E.,
GeddeDahl, Jr T.,
Fischer T.
Publication year - 1974
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1974.tb00288.x
Subject(s) - subclass , cistron , biology , gene , genetics , genetic marker , antibody , microbiology and biotechnology , escherichia coli
SUMMARY A new type of Gm genetic marker combination in an IgG1 immunoglobulin, Gm(z) together with a non‐a marker, is here described. This indicates the presence of a new gene, Gm z,non‐a , which most likely originated on the basis of an intragenic recombination at the IgG1 cistron. Immunochemical and immunogenetic studies showed that no other IgG1 Gm markers were expressed by the unusual gene, and there was no evidence for deletions or duplications at the IgG1 cistron.