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Clinical and laboratory features of adult biphenotypic acute leukemia
Author(s) -
Tong Haixia,
Liu Zhuogang,
Lu Chunwei,
Wang Qiushi
Publication year - 2013
Publication title -
asia‐pacific journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 29
eISSN - 1743-7563
pISSN - 1743-7555
DOI - 10.1111/j.1743-7563.2012.01571.x
Subject(s) - medicine , gastroenterology , spleen , leukemia , lymphoblastic leukemia , incidence (geometry) , acute leukemia , immunology , physics , optics
Aim T o analyze the clinical and biological characteristics of adult BAL . Methods We identified 22 cases (4.4%) of BAL from 496 newly diagnosed acute leukemia patients and compared them with patients with acute myloid leukemia ( AML ) and acute lymphoblastic leukemia ( ALL ). Results CD 34 positivity was higher in BAL (87%) than in ALL (60%, P = 0.04) and AML patients (63%, P = 0.05). The median age in the BAL group was greater than in ALL (43 vs 31 years, P = 0.04). Enlargement of liver, spleen and lymphonodes was more common in BAL (81.8%) than AML (46%, P = 0.003). Cytogenetic analysis revealed abnormal karyotypes in 56% of BAL patients. The overall completed remission rate in the BAL group (65%) was lower than in ALL (86%, P = 0.04). Conclusion BAL patients showed a much higher incidence of older age, CD 34 antigen expression, presence of Philadelphia chromosome, liver, spleen and lymphonodes infiltration and resistance to therapy.