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Pilot study evaluating the role of cardiac magnetic resonance imaging in monitoring adjuvant trastuzumab therapy for breast cancer
Author(s) -
LAWLEY Claire,
WAINWRIGHT Camilla,
SEGELOV Eva,
LYNCH Jodi,
BEITH Jane,
MCCROHON Jane
Publication year - 2012
Publication title -
asia‐pacific journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 29
eISSN - 1743-7563
pISSN - 1743-7555
DOI - 10.1111/j.1743-7563.2011.01462.x
Subject(s) - trastuzumab , medicine , breast cancer , magnetic resonance imaging , oncology , cancer , adjuvant , adjuvant therapy , medical physics , radiology
Aim: To explore the incidence of subclinical cardiotoxicity in women treated with adjuvant trastuzumab in the early breast cancer setting using cardiac magnetic resonance imaging (cMRI). Methods: The cardiac function and myocardial tissue characteristics of 25 women who had completed adjuvant trastuzumab therapy greater than 6 months previously was evaluated using MRI and comparing this with symptoms and routine echocardiography. Results: Evidence of myocardial tissue damage was seen in two women in the absence of functional change or previous cardiac symptoms. Conclusion: Tissue characterization using cMRI may provide a useful tool in defining trastuzumab induced cardiotoxicity.