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Interdigitating dendritic cell sarcoma of the tonsil
Author(s) -
KIM Sun Young,
KANG JinHyoung,
CHUN Sang Hoon,
CHANG Myung Hee,
KIM YeonSil,
LEE Sang Nam,
KIM MinSik,
KANG ChangSuk
Publication year - 2010
Publication title -
asia‐pacific journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 29
eISSN - 1743-7563
pISSN - 1743-7555
DOI - 10.1111/j.1743-7563.2010.01298.x
Subject(s) - medicine , tonsil , vincristine , malignancy , lymph node , cervical lymph nodes , prednisone , pathology , cyclophosphamide , chemotherapy , surgery , metastasis , cancer
Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare malignancy derived from antigen‐presenting cells, with 55 cases reported thus far. A standard treatment modality is still being debated. This report describes a 56‐year‐old female who presented with right tonsillar enlargement and right submandibular swelling for 6 months. Treatment with empiric antibiotics did not result in improvement of her symptoms. Fine needle aspiration of the tonsil revealed no malignant cells. Tonsillectomy was eventually performed due to persistent symptoms. Based on microscopic findings, immunohistochemical stains, and review of the literature, the present case was finally diagnosed as IDCS of the tonsil with cervical lymph node involvement. The patient received four cycles of CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) chemotherapy, and a clinically complete response was achieved followed by adjuvant radiation.