Non‐metastatic cholestatic paraneoplastic syndrome associated with soft tissue sarcoma

Paraneoplastic syndromes have been described in association with variety of malignant neoplasms. The non‐metastatic cholestatic paraneoplastic syndrome first described as Stauffer's syndrome in association with renal cell carcinomas is also associated with other malignancies. We describe the autopsy findings of a patient with recurrent and metastatic leiomyosarcomas presenting with cholestatic liver dysfunction. The diagnosis requires the exclusion of all other possible causes of hepatitis and, where possible, resolution after the effective treatment of the underlying malignancy.