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New insights into human enteric neuropathies
Author(s) -
De Giorgio R.,
Guerrini S.,
Barbara G.,
Cremon C.,
Stanghellini V.,
Corinaldesi R.
Publication year - 2004
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/j.1743-3150.2004.00491.x
Subject(s) - enteric nervous system , achalasia , irritable bowel syndrome , medicine , chronic constipation , gut–brain axis , disease , intestinal pseudo obstruction , functional gastrointestinal disorder , constipation , hirschsprung's disease , pathology , gastroenterology , neuroscience , bioinformatics , biology , esophagus
The functioning of enteric neuronal circuitries has been elucidated in the recent past. Evidence is now gathering to explain how dysfunction of the enteric nervous system (ENS) may lead to human gastrointestinal motor disorders. These conditions include achalasia, congenital hypertrophic pyloric stenosis, chronic intestinal pseudo‐obstruction, Hirschsprung's disease, chronic idiopathic constipation, and probably irritable bowel syndrome. Degenerative, inflammatory and genetic mechanisms exert a critical role in ENS dysfunction underlying gut dysmotility. The study of the ENS abnormalities in gut dysmotility provides a framework to better understand the mechanisms involved in degeneration and neuronal loss and fosters the development of targeted therapeutic options.