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Selenium Modulates Oxidative Stress‐Induced TRPM 2 Cation Channel Currents in Transfected Chinese Hamster Ovary Cells
Author(s) -
Nazıroğlu Mustafa,
Özgül Cemil,
Küçükayaz Mustafa,
Çiğ Bilal,
Hebeisen Simon,
Bal Ramazan
Publication year - 2013
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/j.1742-7843.2012.00934.x
Subject(s) - chinese hamster ovary cell , transient receptor potential channel , oxidative stress , patch clamp , microbiology and biotechnology , transfection , chemistry , cell culture , hamster , cricetulus , cytosol , selenium , biophysics , receptor , biochemistry , biology , genetics , organic chemistry , gene , enzyme
It has been recently reported that the essential antioxidant element selenium has protective effects on cytosolic C a 2+ levels in cell lines. However, the effects of selenium on like transient receptor potential melastatin 2 ( TRPM 2) in response to oxidative stress ( H 2 O 2 ) are not well understood. We investigated the effects of selenium on H 2 O 2 ‐induced TRPM 2 channel currents in the C hinese hamster ovary ( CHO ) cell line using patch‐clamp and fura‐2 fluorescence imaging techniques.