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The Role of Waixenicin A as Transient Receptor Potential Melastatin 7 Blocker
Author(s) -
Kim Byung J.,
Nam Joo H.,
Kwon Young K.,
So Insuk,
Kim Seon J.
Publication year - 2013
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/j.1742-7843.2012.00929.x
Subject(s) - transient receptor potential channel , medicine , trpm2 , adenocarcinoma , cancer research , motility , apoptosis , electrophysiology , endocrinology , receptor , pharmacology , microbiology and biotechnology , cancer , chemistry , biology , biochemistry
Transient receptor potential melastatin 7 ( TRPM 7) plays a role in a number of physiological and pharmacological functions in variety of cells. The aim of this study was to clarify the role for TRPM 7 channels and the effect of waixenicin A on the pacemaking activity of interstitial cells of C ajal ( ICC s) and on the cell viability of the human gastric and breast adenocarcinoma cell lines, AGS and MCF ‐7, respectively. Waixenicin A decreased the amplitude of pacemaker potentials in cultured ICC clusters and inhibited TRPM 7 currents, but had no effect on C a 2+ ‐activated Cl − conductance ( ANO 1). Furthermore, waixenicin A was found to inhibit the growth and survival of AGS and MCF ‐7 cells. These findings indicate that TRPM 7 channel modulates intestinal motility and regulates the pathophysiology of human gastric and breast adenocarcinoma cells. These findings suggest that TRPM 7 channel be considered a potential target for the treatment of gut motor disorders and gastric and breast cancer.