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A Comparison of the Potency of a Novel Bispyridinium Oxime K203 and currently available Oximes (Obidoxime, HI ‐6) to Counteract the Acute Neurotoxicity of Sarin in Rats
Author(s) -
Kassa Jiri,
Misik Jan,
Karasova Jana Zdarova
Publication year - 2012
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/j.1742-7843.2012.00897.x
Subject(s) - sarin , potency , oxime , neurotoxicity , pharmacology , chemistry , medicine , biochemistry , toxicity , acetylcholinesterase , organic chemistry , in vitro , enzyme
The neuroprotective effects of a newly developed oxime K203 and currently available oximes (obidoxime, HI ‐6) in combination with atropine in rats poisoned with sarin were studied. The sarin‐induced neurotoxicity was monitored using a functional observatory battery at 2 hr after sarin challenge. The results indicate that the potency of a novel bispyridinium oxime K203 to counteract sarin‐induced neurotoxicity is relatively low and roughly corresponds to the neuroprotective efficacy of obidoxime. Among tested oximes, the oxime HI ‐6 seems to be significanlty more efficacious to counteract acute neurotoxicity of sarin than commonly used obidoxime and a newly developed oxime K203. Thus, the oxime K203 does not provide any beneficial effect for the antidotal treatment of acute poisoning with sarin in comparison with the oxime HI ‐6 that should be considered to be the best oxime for antidotal treatment of acute sarin poisonings.