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Percutaneous Catheter‐based Intracoronary Infusion of Insulin – A Dose Finding Study in the Porcine Model
Author(s) -
Slettom Grete,
Jonassen Anne K.,
Tuseth Vegard,
Pettersen Reidar J.,
Larsen Terje H.,
Seifert Reinhard,
Nordrehaug Jan E.
Publication year - 2011
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/j.1742-7843.2011.00672.x
Subject(s) - medicine , insulin , in vivo , myocardial infarction , catheter , ex vivo , cardiology , percutaneous , percutaneous coronary intervention , anesthesia , surgery , biology , microbiology and biotechnology
Insulin given at immediate reperfusion reduces myocardial infarct size in the in vitro and the ex vivo rat heart. In vivo , insulin may cause hypoglycaemia, hypokalaemia and elevation of catecholamines, potentially harmful during an acute myocardial infarction. The purpose of this study was to evaluate tolerance and safety of intracoronary insulin infusions in a porcine model applying percutaneous intervention techniques.