Premium
Anti‐Inflammatory and Analgesic Activities of the Aqueous Extract of Acacia karroo Stem Bark in Experimental Animals
Author(s) -
Adedapo Adeolu A.,
Sofidiya Margaret O.,
Masika Patrick J.,
Afolayan Anthony J.
Publication year - 2008
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/j.1742-7843.2008.00317.x
Subject(s) - analgesic , acacia , carrageenan , traditional medicine , bark (sound) , aqueous extract , gum acacia , histamine , pharmacology , medicine , chemistry , botany , biology , food science , ecology
The aqueous extract of the stem bark of Acacia karroo Hayne was investigated for its anti‐inflammatory and analgesic activities in animal models. The extract at 100 and 200 mg/kg reduced significantly the formation of oedema induced by carrageenan and histamine. In the acetic acid‐induced writhing model, the extract showed a good analgesic effect characterized by a significant reduction in the number of writhes with two doses (100 and 200 mg/kg) used when compared to the untreated control group. In the tail immersion test, the extract at the doses used (100 and 200 mg/kg) increased reaction time to pain after 30 min. of oral administration of the extract. Indomethacin at 10 mg/kg served as reference drug in all these tests. The results gave a scientific basis to the traditional uses of Acacia karroo mainly for wound poultices, eye treatments and cold remedies.