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The Role of Route of Vitamin E Administration on the Plasma Antioxidant Activity and Lipid Peroxidation in Newborn Calves
Author(s) -
MokhberDezfouli Mohammad Reza,
Rahimikia Edris,
Asadi Farzad,
Nadalian Mohammad Gholi
Publication year - 2008
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/j.1742-7843.2008.00308.x
Subject(s) - lipid peroxidation , vitamin e , antioxidant , vitamin , pharmacology , medicine , chemistry , biochemistry
The aim of our study was to evaluate plasma values of α‐tocopherol, malondialdehyde (MDA) and antioxidant activity after a single‐dose administration of vitamin E as intramuscular injection, oral supplementation and intramuscular injection plus oral supplementation at 4 hr after birth. Thirty calves were bled at birth and assigned to treatments as follows: control (n = 8), intramuscular injection (40 IU/kg, n = 7), oral supplementation (25 IU/kg, n = 7) and intramuscular injection (20 IU/kg) plus oral supplementation (12.5 IU/kg, n = 8). Blood was collected at 12 and 24 hr after birth and plasma α‐tocopherol, MDA and antioxidant activity values were determined. Results showed that no changes in MDA values were observed after oral administration (P > 0.05). However, antioxidant activity values showed an increase at both 12 (9.57 ± 0.65 mmol/l) and 24 hr (10.42 ± 0.54 mmol/l) after birth when compared to control (3.73 ± 0.75 mmol/l). Injection with or without oral supplementation increased serum antioxidant activity values at 12 (about 102%, 46%) and 24 hr (94%, 115%) after birth, when compared to control. In addition, MDA values were found to be lower in those animals receiving an injection of vitamin E or injection plus oral supplementation of vitamin E as compared to control at both time‐points (P < 0.001). Injection of vitamin E provided beneficial effects to plasma antioxidant activity and MDA values. Therefore, injection may be the best method of vitamin E administration in newborn calves for protecting them in the stressful postnatal condition.