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Dopaminergic but Not Glutamatergic Neurotransmission Is Increased in the Striatum after Selective Cyclooxygenase‐2 Inhibition in Normal and Hemiparkinsonian Rats
Author(s) -
Fathi Moghaddam Hadi,
Ardestani Mehdi Shafiee,
Saffari Mostafa,
Navidpour Latifeh,
Shafiee Abbas,
Rahmim Arman
Publication year - 2008
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/j.1742-7843.2008.00295.x
Subject(s) - pars compacta , glutamatergic , substantia nigra , dopaminergic , neurotransmission , dopamine , striatum , chemistry , microdialysis , pharmacology , neuroscience , glutamate receptor , medicine , biology , biochemistry , receptor
In the present work, we studied the effect of the selective cyclooxygenase‐2 (COX‐2) inhibitors, compound 11 g, celecoxib and selective COX‐1 inhibitor SC‐560 (intraperitoneally and acutely) on striatal glutamatergic and dopaminergic neurotransmission in normal and substantia nigra pars compacta (SNc)‐lesioned rats using the microdialysis technique. We also investigated the effect of acute COX inhibition on the damaged SNc neurons. Our results indicate a significant increase in dopaminergic neurotransmission and a decrease in glutamatergic neurotransmission (P < 0.05) only after selective COX‐2 inhibition in the striatum of normal and hemiparkinsonian rats. Nonetheless, neither COX‐1 nor COX‐2 inhibitors showed any improvement in the damaged SNc neurons.