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Effect of Rosuvastatin on Methionine‐Induced Hyperhomocysteinaemia and Haematological Changes in Rats
Author(s) -
Nigam Gaurav Kumar,
Ansari M. Nazam,
Bhandari Uma
Publication year - 2008
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/j.1742-7843.2008.00293.x
Subject(s) - homocysteine , rosuvastatin , endocrinology , medicine , methionine , cholesterol , very low density lipoprotein , low density lipoprotein , lipoprotein , chemistry , high density lipoprotein , biochemistry , amino acid
The present study was designed to investigate the protective effect of rosuvastatin on methionine‐induced hyperhomocysteinaemia and haematological changes in albino rats. Methionine (1 g/kg, orally) administration to pathogenic control rats (i.e. group II) for 30 days significantly (P < 0.01) increased the levels of homocysteine, total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C), very low‐density lipoprotein cholesterol (VLDL‐C) and triglycerides (TGs) and decreased the levels of high‐density lipoprotein cholesterol (HDL‐C) in serum. Haematological observations of the peripheral blood smears of pathogenic rats (i.e. group II) fed with methionine also showed crenation of red blood cells cell membrane and significant (P < 0.01) increase in total leucocyte count, differential leucocyte count and platelet counts with significant (P < 0.01) decrease in the mean haemoglobin levels as compared to vehicle control rats (group I). Administration of rosuvastatin (0.5 mg/kg/day, orally) to hyperhomocysteinaemic rats for 30 days significantly (P < 0.01) decreased the levels of homocysteine, TC, TGs, LDL‐C, VLDL‐C and increased the levels of HDL‐C in serum. The present results provide clear evidence that oral treatment with rosuvastatin produces homocysteine and lipid lowering activity and also reversal of haematological changes induced by methionine in rats.