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Natural Antioxidant Pedicularioside G Inhibits Angiogenesis and Tumourigenesis in vitro and in vivo
Author(s) -
Mu Ping,
Gao Xue,
Jia ZhongJian,
Zheng RongLiang
Publication year - 2008
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/j.1742-7843.2007.00146.x
Subject(s) - chorioallantoic membrane , angiogenesis , umbilical vein , in vitro , neovascularization , in vivo , human umbilical vein endothelial cell , embryo , biology , microbiology and biotechnology , cell growth , reactive oxygen species , endothelial stem cell , chemistry , biochemistry , pharmacology , cancer research , genetics
Pedicularioside G is a new compound of phenylpropanoid glycosides, isolated from Pedicularis striata in our laboratory. Pedicularioside G inhibited two major angiogenic responses, human umbilical vein endothelial cell proliferation and migration, as well as neovascularization in a chicken embryo chorioallantoic membrane model. In addition, pedicularioside G inhibited human hepatoma cells proliferation and migration in vitro along with transplanting tumour formation and growth in a chicken embryo chorioallantoic membrane model. So pedicularioside G has anti‐angiogenic, antitumour growth, antimetastatic and antitumoural effects. Pedicularioside G also remarkably reduced reactive oxygen species level in both vein endothelial cells and hepatoma cells in a concentration‐dependent manner. These results suggest that the anti‐angiogenic and antitumoural effects of pedicularioside G might partially attribute to its antioxidative activity.