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Carvedilol Increases Copper‐Zinc Superoxide Dismutase Activity in Patients with Acute Myocardial Infarction
Author(s) -
Kastratović Dragana A.,
Vasiljević Zorana M.,
Spasić Mihajlo B.,
Perunicić Jovan P.,
Matić Mihajlo,
Blagojević Dusko P.,
Mijalković Dejan N.,
Antonijević Nebojsa M.,
Marković Srdjan Z.,
GojkovićBukarica Ljiljana,
Stojiljkovic Milos P.,
Lasica Ratko M.,
Jones David R.,
NikolićKokić Aleksandra L.
Publication year - 2007
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/j.1742-7843.2007.00094.x
Subject(s) - carvedilol , streptokinase , metoprolol , superoxide dismutase , glutathione peroxidase , pharmacology , catalase , myocardial infarction , antioxidant , glutathione reductase , superoxide , chemistry , medicine , heart failure , biochemistry , enzyme
Balanced and coordinated antioxidant defence enzyme activities are of utmost importance for correct physiological function and for shielding against unwelcome pathological conditions. We determined the activities of copper‐zinc superoxide dismutase (CuZnSOD), catalase, glutathione peroxidase and glutathione reductase in erythrocytes isolated from patients receiving different therapy (streptokinase alone or in combination with metoprolol or with carvedilol) for up to 168 hr after starting treatment for acute myocardial infarction. We observed increased CuZnSOD activity in erythrocytes isolated from patients treated with streptokinase‐carvedilol (after 6, 24 and 168 hr) and in erythrocytes isolated from patients treated with streptokinase‐metoprolol (after 24 hr). In addition, positive correlation between CuZnSOD and catalase activities was found in erythrocytes isolated from patients that received streptokinase‐carvedilol after 168 hr. As metoprolol does not react directly with hydrogen peroxide, it would appear that combined streptokinase‐metoprolol therapy exerted its effects primarily via by β‐blockade whereas combined streptokinase‐carvedilol therapy appeared to function via both β‐blockade and direct antioxidant mechanisms.