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Association of Angiotensin‐Converting Enzyme Gene Insertion/Deletion Polymorphism with Allergic Contact Dermatitis
Author(s) -
Nacak Muradiye,
Erbagci Zulal,
Buyukafsar Kansu,
Yurtsever Ahmet Sencer,
Tiftik Rukiye Nalan
Publication year - 2007
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/j.1742-7843.2007.00077.x
Subject(s) - genotype , angiotensin converting enzyme , allele , allergic contact dermatitis , polymorphism (computer science) , medicine , polymerase chain reaction , contact dermatitis , gene polymorphism , immunology , allele frequency , gene , allergy , genetics , biology , blood pressure
Angiotensin‐converting enzyme (ACE) plays an important role in the physiological control of blood pressure and inflammation. Insertion/deletion (I/D) polymorphism of the gene for ACE was investigated in relation to cardiovascular, cerebrovascular, neurodegenerative and inflammatory diseases. The purpose of the present study was to investigate the possible association between allergic contact dermatitis and insertion/deletion polymorphism of the ACE gene. A total of 90 patients with allergic contact dermatitis and 160 control persons were enrolled in the present study. ACE I/D genotypes were determined by the polymerase chain reaction. Allelic frequencies and genotype distribution of the ACE I/D polymorphism in the patient group were significantly different from control group (ACE II genotype 30.0% versus 17.5%, P = 0.022; ACE I allele 51.7% versus 39.4%, P = 0.008). Our data suggest that the ACE polymorphism could be a risk factor for patients with allergic contact dermatitis.