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N‐Benzoyl‐D‐phenylalanine Attenuates Brain Acetylcholinesterase in Neonatal Streptozotocin‐Diabetic Rats
Author(s) -
Ashokkumar Natarajan,
Pari Leelavinothan,
Ramkumar Kunga Mohan
Publication year - 2006
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/j.1742-7843.2006.pto_487.x
Subject(s) - acetylcholinesterase , tbars , lipid peroxidation , thiobarbituric acid , endocrinology , diabetes mellitus , aché , streptozotocin , medicine , cholinergic , neurotransmitter , phenylalanine , pharmacology , chemistry , biochemistry , enzyme , oxidative stress , central nervous system , amino acid
The effect of hyperglycaemia due to experimental diabetes in male Wistar rats causes a decrease in the level of acetylcholinesterase (AChE) with significant increase in lipid peroxidative markers: thiobarbituric acid‐reactive substances (TBARS) and hydroperoxides in brains of experimental animals. The decreased activity of both salt soluble and detergent soluble acetylcholinesterase observed in diabetes may be attributed to lack of insulin which causes specific alterations in the level of neurotransmitter, thus causing brain dysfunction. Administration of non‐sulfonylurea drug N‐benzoyl‐D‐phenylalanine (NBDP) could protect against direct action of lipid peroxidation on brain AChE and in this way it might be useful in the prevention of cholinergic neural dysfunction, which is one of the major complications in diabetes.