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The Effect of Vasopressin and Related Compounds at V 1a and V 2 Receptors in Animal Models Relevant to Human Disease *
Author(s) -
Petersen Mads Bjelke
Publication year - 2006
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/j.1742-7843.2006.pto_299.x
Subject(s) - vasopressin , diabetes insipidus , vasopressin receptor , medicine , septic shock , receptor , arginine vasopressin receptor 2 , agonist , arginine vasopressin receptor 1b , endocrinology , sepsis , homeostasis , shock (circulatory) , animal studies , antagonist
Vasopressin, a neurohypophyseal peptide hormone, is the endogenous agonist at V 1a , V 1b and V 2 receptors. The most important physiological function of vasopressin is the maintenance of water homeostasis through interaction with V 2 receptors in the kidney. Vasopressin and related compounds are used in various clinical settings such as acute variceal bleeding associated with portal hypertension, septic shock, diabetes insipidus and coagulation disorders. The effect in the former two indications relates to the V 1a receptor, and in the two latter indications the effect relates to the V 2 receptor. Vasopressin and related compounds have demonstrated activity in animal models of portal hypertension, sepsis and septic shock, diabetes insipidus and coagulation disorders. The use of the compounds in animal models is reviewed. Generally, the effect of vasopressin and related compounds in animal models reflect the activity in the clinical setting, but in some cases important species differences exist.