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Modulatory Effect of Ficus racemosa : Diminution of Potassium Bromate‐Induced Renal Oxidative Injury and Cell Proliferation Response
Author(s) -
Khan Naghma,
Sultana Sarwat
Publication year - 2005
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/j.1742-7843.2005.pto_163.x
Subject(s) - chemistry , potassium bromate , lipid peroxidation , blood urea nitrogen , xanthine oxidase , oxidative stress , pharmacology , glutathione , tumor promotion , endocrinology , medicine , ornithine decarboxylase , nephrotoxicity , creatinine , biochemistry , kidney , enzyme , carcinogenesis , gene , catalysis
The aim of the present study was to determine the potential beneficial effects of Ficus racemosa extract. Potassium bromate (KBrO 3 ), a potent nephrotoxic agent that induces renal carcinogenesis and acts as tumour promoter in carcinogen‐initiated animals was used as a model to induce renal injury. In this study, we show the chemopreventive effect of Ficus racemosa extract (Moraceae) on KBrO 3 ‐mediated renal oxidative stress and cell promotion response in rats. KBrO 3 (125 mg/kg body weight, intraperitoneally) enhanced lipid peroxidation, xanthine oxidase, γ‐glutamyl transpeptidase and hydrogen peroxide (H 2 O 2 ) generation with reduction in renal glutathione content and antioxidant enzymes. KBrO 3 treatment also induced tumour promotion markers, viz., ornithine decarboxylase activity and thymidine [ 3 H] incorporation into renal DNA. A sharp elevation in the levels of blood urea nitrogen and serum creatinine has also been observed. Treatment of rats orally with Ficus racemosa extract (200 mg/kg body weight and 400 mg/kg body weight) resulted in a significant decrease in xanthine oxidase (P<0.05), lipid peroxidation (P<0.001), γ‐glutamyl transpeptidase (P<0.001) and H 2 O 2 (P<0.001). There was significant recovery of renal glutathione content (P<0.01) and antioxidant enzymes (P<0.001). There was also reversal in the enhancement of renal ornithine decarboxylase activity, DNA synthesis, blood urea nitrogen and serum creatinine (P<0.001). Our results suggest that Ficus racemosa extract is a potent chemopreventive agent and suppresses KBrO 3 ‐mediated nephrotoxicity in rats.