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Optimizing Drug Regimens in Cancer Chemotherapy
Author(s) -
Iliadis Athanassios
Publication year - 2005
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/j.1742-7843.2005.pto960326.x
Subject(s) - etoposide , drug , chemotherapy , pharmacodynamics , medicine , pharmacology , toxicity , pharmacokinetics , cisplatin , absolute neutrophil count , platelet , teniposide , cancer , neutrophil extracellular traps , oncology , neutropenia , inflammation
In cancer chemotherapy, it is important to design treatment strategies that ensure a desired rate of tumor cell kill without unacceptable toxicity. To optimize treatment, we used a mathematical model describing the pharmacokinetics of anticancer drugs, antitumor efficacy, and drug toxicity. This model was associated with constraints on the allowed drug concentrations and amounts, neutropenia, thrombopenia and their recovery levels before the next cycle of chemother- apy. Given a schedule of drug administrations, the mathematical model optimized the drug doses that can minimize the tumor burden while limiting hemotoxicity.