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Internal Exposure of Children by Simulated Acute Inhalation of Volatile Organic Compounds: The Influence of Chemical Properties on the Child/Adult Concentration Ratio
Author(s) -
Abraham Klaus,
Mielke Hans,
Huisinga Wilhelm,
GundertRemy Ursula
Publication year - 2005
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/j.1742-7843.2005.pto960315.x
Subject(s) - inhalation , physiology , chemistry , context (archaeology) , physiologically based pharmacokinetic modelling , inhalation exposure , partition coefficient , environmental chemistry , pharmacokinetics , medicine , anesthesia , chromatography , biology , paleontology
A specific exposure scenario, namely the accidental release of industrial chemicals leading to an airborne exposure over a wide range of concentrations, requires special\udconsideration in the risk assessment including that of sensitive subpopulations. In this context, children may be at higher risk compared to adults due to possible higher\udexternal exposure (behaviour, physiology), different kinetics (both leading to higher internal exposure) and different dynamics. The scope of this paper is the\udquantification of the age-dependent differences in the kinetics of children occurring during inhalation of volatile organic compounds (VOCs)