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Which in vitro Screens Guide the Prediction of Oral Absorption and Volume of Distribution?
Author(s) -
Van De Waterbeemd Han
Publication year - 2005
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/j.1742-7843.2005.pto960304.x
Subject(s) - adme , in silico , pharmacokinetics , volume of distribution , in vitro , absorption (acoustics) , drug discovery , computational biology , distribution (mathematics) , pharmacology , chemistry , biochemical engineering , biology , biochemistry , materials science , mathematics , mathematical analysis , composite material , engineering , gene
The development of medium to high‐throughput in vitro screening of ADME (Absorption, Distribution, Metabolism, Excretion) properties has been the reply to higher demands on drug metabolism scientists to cope with progress in chemistry and biology. Two areas will be discussed here, namely screens for oral absorption and for volume of distribution. The prediction of these human pharmacokinetic parameters can be based on proper combination of simple physicochemical measurements. In the future in vitro screens most likely will be combined with in silico assessments of various ADME properties leading to the concept of in combo screening in drug discovery.