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Adenosine A 1 Receptor Blockade Mimics Caffeine's Attenuation of Ethanol‐Induced Motor Incoordination
Author(s) -
Connole Laura,
Harkin Andrew,
Maginn Mark
Publication year - 2004
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/j.1742-7843.2004.pto950509.x
Subject(s) - caffeine , adenosine receptor , pharmacology , adenosine receptor antagonist , adenosine , chemistry , ethanol , antagonist , motor coordination , adenosine a1 receptor , inhibitory postsynaptic potential , medicine , receptor , biochemistry , agonist , psychiatry
The effects of co‐administration of caffeine and ethanol were assessed on the motor coordination of rats on the accelerating rotarod (accelerod). Ethanol (2.5 g/kg, orally) decreased motor performance on the accelerod. Co‐administration of caffeine (5 and 20 mg/kg, orally) dose‐dependently attenuated this ethanol‐induced deficit. Caffeine (20 mg/kg, orally) alone did not affect motor performance in the test. As caffeine is a non‐selective adenosine receptor antagonist the ability of adenosine A 1 and A 2A receptor blockade to attenuate ethanol‐induced motor incoordination was determined. Pre‐treatment with the adenosine A 1 receptor antagonist DPCPX (5 mg/kg, intraperitoneally) attenuated ethanol (2.5 g/kg, orally)‐induced motor incoordination. By contrast, prior administration of the adenosine A 2A selective antagonist SCH 58261 (10 mg/kg intraperitoneally) had no effect on the ethanol‐induced motor deficit. These data demonstrate that adenosine A 1 receptor blockade mimics the inhibitory action of caffeine on ethanol‐induced motor incorordination, and may contribute to the ability of caffeine to offset the acute intoxicating actions of ethanol.